Phenylephrine should be given to a pregnant woman only if clearly needed. His team interviewed 12,700 moms of babies with birth defects that weren't caused by chromosomes and compared them to 7,600 babies without deformities. (2020). If you take too much phenylephrine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. Is the ketogenic diet right for autoimmune conditions? (2020). Learn more. Cookies collect information about your preferences and your device and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Use is not recommended unless clearly needed.AU TGA pregnancy category: B2US FDA pregnancy category: C Comments:-There is no data on use in pregnant women to know this drugs risks, including the risk of fetal harm or reproductive effects. Especially tell your doctor if you: Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. 2023 The Heart & Brain. Examples of MAOIs include: The combination of MAOIs with certain classes of drugs including selective serotonin reuptake inhibitors, serotoninnorepinephrine reuptake inhibitors, and tricyclic antidepressants in some oral decongestants, can cause serotonin syndrome (SS). Glad you feel better, I took that two nights in a row and it's on my safe list from the hospital. information submitted for this request. A single copy of these materials may be reprinted for noncommercial personal use only. To provide you with the most relevant and helpful information, and understand which We comply with the HONcode standard for trustworthy health information. Common side effects of phenylephrine include nausea, vomiting, and headache. Well, after taking the pill, I stupidly decide to do a search for each ingredient, and while all of the other ingredients were considered perfectly safe, there were not such good reviews for phenylephrine. Anyone experiencing side effects or possible interaction between a nasal decongestant and their regular medication should speak with a healthcare professional. WebSide effects Pregnancy, breastfeeding and fertility Taking it with other medicines and herbal supplements Common questions Related conditions Allergies Common cold Cough Hay fever Sinusitis (sinus infection) Useful resources HealthUnlocked: Sudafed forum healthunlocked.com Allergy UK: charity www.allergyuk.org Is it safe to take cough remedies containing phenylephrine while pregnant? I wouldn't worry yourself. I personally hate this menthol effect because it burns my esophagus and stomach (which is why it didnt sit well with me) but I digress. Label: Sudafed pseudoephedrine hydrochloride tablet, coated [Fact sheet]. SOURCE: bit.ly/17mAbMT American Journal of Epidemiology, online July 3, 2013. Progestin-only pills (POPs) for contraception. MNT is the registered trade mark of Healthline Media. Image: Shutterstock Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage.US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Cold-like symptoms may make your nasal passage extremely congested. What are the best nasal decongestants by age? Webpharmacist before taking any NSAIDs during pregnancy.3,4 What can I take for allergies and hayfever? She went o Dr. Gibson is a pharmacist and medical communicator. Our Standards: The Thomson Reuters Trust Principles. Use of imidazolines (found in nasal decongestant sprays and eye drops) was tied to an approximate doubling of risk for an abnormal connection between the trachea and esophagus. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. https://www.uptodate.com/contents/search. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. There is a problem with Eventually, that reduces the conditions to allow for normal breathing. They found no link between the medications and several other deformities that had been suggested by previous studies, such as clubfoot or defects of the eye or face, according to the report published in the American Journal of Epidemiology. By using our website, you consent to our use of cookies. Use these dosage charts for infants and children under 12 years old: The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not drive or operate heavy machinery until you know how phenylephrine affects you. a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), oxytocic drugs such as oxytocin (Pitocin), tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil), angiotensin-converting enzyme (ACE) blockers such as benazepril (Lotensin, Lotensin HCT), captopril (Capoten, Capozide), enalapril (Vasotec, Vaseretic), fosinopril (Monopril, Monopril HCT), lisinopril (Prinivil, Prinzide, Zestril, Zestoretic), moexipril (Univasc, Uniretic), quinapril (Accupril, Accuretic, Quinaretic), ramipril (Altace), and trandolapril (Mavik, Tarka), angiotensin receptor II blockers such as azilsartan (Edarbi), candesartan (, norepinephrine transporter inhibitors, such as atomoxetine (Strattera), ergot alkaloids, such as methylergonovine maleate, -adrenergic antagonists such as doxazosin (Cardura) and prazosin (Minipress), phosphodiesterase type 5 inhibitors such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Cialis), vardenafil (Levitra), certain medications for high blood pressure such as carvedilol (Coreg) and labetalol, calcium channel blockers, such as nifedipine (Adalat, Nifedical, Procardia), amlodipine (Norvasc), verapamil (Calan, Isoptin, Covera, Verelan), and diltiazem (Cardizem). But for the first time, the authors found links between first-trimester use of pseudoephedrine (also in Sudafed) and a 3-fold higher risk of so-called limb reduction defects. First-trimester use of phenylephrine, which is found in Sudafed among other products, was tied to an eight-fold higher risk of a heart defect called endocardial cushion defect. This site complies with the HONcode standard for trustworthy health information: verify here. The dose your doctor recommends may be based on the condition being treated. Medically reviewed by Drugs.com. However, the doctors must also do due diligence on the pregnant womens medication history if the information is not given voluntarily by the patient. PHENYLEPHRINE HYDROCHLORIDE- phenylephrine hydrochloride injection, DailyMed: Current Medication Information; U.S. National Library of Medicine. A woman who uses decongestant medications like pseudoephedrine while in the first trimester of pregnancy Nurses had interviewed the mothers of babies with birth defects not caused by chromosome problems, and Mitchells group analyzed the results for a total of 12,700 infants, comparing them to answers from the mothers of 7,600 infants without deformities. Animal studies have not been conducted. Follow the directions on your prescription label carefully. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. health information, we will treat all of that information as protected health They are both decongestants and have similar effects. Phenylephrine falls into category C. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Phenylephrine is commonly found in over-the-counter cold and allergy medications. Phenylephrine For a pregnant woman or any other person, it is not set in stone that you should purchase over-the-counter medicines to deal with common problems such as nasal congestion. We all know that drugs may have different effects or functionalities based on the mode of introduction into the body. While there may not be a lot of research concretely proving that Tylenol during pregnancy is safe, the lack of data for adverse effects leads experts to largely acetaminophen chlorpheniramine codeine dextromethorphan doxylamine guaifenesin ibuprofen promethazine, those with a preexisting medical condition, individuals taking any kind of medication. Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage.US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Stop using phenylephrine ophthalmic and call your doctor at once if you have: fast or irregular heart rate; sweating, tremors; pale skin, light-headed feeling; severe headache, buzzing in your ears, anxiety, shortness of breath; or chest pain or pressure, pain spreading to your jaw or shoulder. But know that there is little risk of birth defects. Normally, the first thing you'd do is reach for the nearest decongestant. Doctors refer to this as rhinitis medicamentosa, or rebound congestion. Never use this subreddit as your first and final source of information regarding your question. TGA. (2019). This medication is considered relatively safe in pregnancy (category c). I accidentally used phenylephrine hcl 0.25% hemorrhoid gel on my back (instead of hydrocortisone 1%). Constriction of the blood vessels in the nose can provide short-term relief from nasal congestion. Phenylephrine is not considered safe for pregnant women, especially during the first trimester, because of its association with birth defects. You probably know pregnant women dont use over-the-counter medication. nervousness. Cate Aside from the fact that decongestant nose sprays can cause rebound congestion if used for more than 3 days in a row, the FDA assigns phenylephrine pr You need to take only the recommended dose. 2016; doi:10.1136/bmj.h6712. Overall, the safety of phenylephrine during pregnancy is not certain. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. We will also briefly discuss ways to deal with cold-like symptoms without any medications for pregnant women. I've done that with my last pregnancy and when I'm not pregnant. An older study from 2003 investigated the effect of pseudoephedrine on milk production and the infants exposure through breast milk. Immediate release tablets: 30 mg or 60 mg. Medications can interact with certain foods. All rights reserved. Individuals can find phenylephrine in various over-the-counter medications for cold, flu, and allergy symptoms. -Routine use of acetaminophen during pregnancy is not advised.-Phenylephrine is a sympathomimetic used in emergencies to treat hypotension and alleviate eye and ear allergic symptoms.-Phenylephrine could cause constriction in uterine vessels (that are normally maximally dilated during pregnancy), reducing uterine blood flow, potentially causing fetal hypoxia.-Phenylephrine may interact with oxytocic or ergot derivatives to cause persistent maternal hypertension; cerebral vessel rupture is possible.-Sympathomimetic amines are teratogenic in some animal models, but are not suspected to cause human teratogenicity.-First trimester exposure to phenylephrine may be linked to fetal abnormalities.-Patients with a preeclampsia history should use phenylephrine with caution due to its vasoconstrictive properties.-Phenylephrine may reduce placental perfusion. Pseudoephedrine and phenylephrine are pregnancy category C in all three trimesters of pregnancy. People who are pregnant or breastfeeding should speak with a doctor before taking nasal decongestants. Immediate release: Take 60 mg every 46 hours, when needed. The shortness in blood flow may eventually result in defects during birth that may not be reversible and very regrettable. Since pseudoephedrine and phenylephrine belong to the same medication class, they can cause similar side effects. They can relieve sinus pressure and nasal congestion. Available for Android and iOS devices. And phenylpropanolamine was linked to an eight times higher risk of defects of the ear and stomach. Is it safe for pregnant women to take chlorpheniramine and phenylephrine? Therapeutic Goods Administration. Pseudoephedrine and phenylephrine are medications that can help alleviate nasal congestion. What Pregnant People Need to Know About COVID-19, Pregnancy Pampering: What's Safe, What's Not, Relieving Cold Symptoms Without Toddler Cough Suppressants, COVID-19 Vaccine During Pregnancy: Everything Parents Should Know, The Best Allergy Medicines and Treatments for Kids. Mayo Clinic. The manufacturer makes no recommendation regarding use during lactation.Excreted into human milk: UnknownExcreted into animal milk: Data not availableComments:-Animal data indicate this drug may decrease milk production. There are no adequate scientific studies to prove the safe use of the decongestant medication phenylephrine when pregnant. First-trimester exposure may have harmful fetal outcomes, but the intranasal application has a lower risk. Too much phenylephrine may worsen congestion, increase blood pressure, or decrease heart rate, among other side effects. For these, please consult a doctor (virtually or in person). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. If you are a Mayo Clinic patient, this could Moms were asked what medications they took while pregnant and in the two months before becoming pregnant. WebWhat if I accidentally took phenylephrine while pregnant? AU TGA pregnancy category B2: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Antidepressant withdrawal symptoms occur when a person stops taking or drastically reduces their dose of antidepressants. Diphenhydramine (this common drug may cause uterine contractions, so in the third trimester it should be used only under the direction of your doctor) The cough He said any type of Sudafed, Tylenol Cold, or guifenisin cough syrup (Robutussin) was all ok, but nothing else. All Rights Reserved. In some states, the drug is only available to people over the age of 18 years. As such, people need to check the medication label to find out the exact dose of each ingredient. Accessed July 15, 2022. privacy practices. Understand though there is Sudafed (phenylephrine) and Sudafed (pseudoephedrine) I know pseudoephedrine is on my safe list but I really don't know about the other. If we combine this information with your protected They carry several risks, depending on the stage of pregnancy: First trimester. The mod team does their best to remove bad information, but we do not catch all of it. are linked to rare birth defects of the digestive tract, ear and heart. (2020). WebSynthroid is FDA pregnancy category A - it is definitely secure for breastfeeding Synthroid or Levothyroxine in its generic form, is a a commonly used medication to treat Hypothyroidism, an underactive thyroid. Everything has been fine :) I also take Claritin everyday for my allergies as well. If they take an MAOI to treat a chronic condition, it may not be safe to stop the medication, and they need to speak with their doctor for further guidance. Store phenylephrine for injection at room temperature. Pregnancy categories A, B, C, D, and X are being phased out. NEW YORK (Reuters Health) - A womans use of decongestant medications in the first trimester of pregnancy may raise her childs risk of certain rare birth defects, according to a small study. Ask a doctor or medical professional on Reddit! 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Result in defects during birth that may not be reversible and very regrettable interviewed 12,700 moms of babies birth. And the infants exposure through breast milk only if clearly needed hydrochloride tablet coated. The effect of pseudoephedrine on milk production and the infants exposure through breast milk, B,,! Take for allergies and hayfever for my allergies as well that information as protected They! Medically appropriate ) I also take Claritin everyday for my allergies as well that my... That reduces the conditions to allow for normal breathing feels the prescriptions are medically appropriate belong to the same class. Nausea, vomiting, and X are being phased out of introduction into body. When needed allergies and hayfever times higher risk of defects of the digestive,! [ Fact sheet ], people need to check the medication label to find the... This as rhinitis medicamentosa, or decrease heart rate, among other side effects subreddit as first!
